Endocrine Abstracts

Introduction: RAGE activation plays a pivotal role in the pathogenesis of diabetic vasculopathy, however the signal transduction mechanism downstream of RAGE is not fully understood. Yoshimoto et al. previously established the RAGE-overexpressed vascular smooth muscle cell line, RAGE-A10, and found that its slow growth rate and increased monocyte chemotactic protein-one (MCP-1) mRNA expression were analogous to the phenomenon of senescence. Senescent cells display characterist...